Last edited by Yorn
Tuesday, July 14, 2020 | History

7 edition of Role of Somatostatin Analogues in Oncology found in the catalog.

Role of Somatostatin Analogues in Oncology

European Neuroendocrine Tumour Network (Enet) February 24-27, 2000 Innsbruck, Austria (Digestion)

by Kjell Oberg

  • 270 Want to read
  • 8 Currently reading

Published by Not Avail .
Written in

    Subjects:
  • Chemotherapy,
  • Gastroenterology,
  • Life Sciences - Biochemistry,
  • Oncology,
  • Cancer,
  • Hormones,
  • Medical

  • The Physical Object
    FormatPaperback
    Number of Pages112
    ID Numbers
    Open LibraryOL12931029M
    ISBN 103805569319
    ISBN 109783805569316
    OCLC/WorldCa45056499

    Dr. Scott Paulson, medical director for the Neuroendocrine Research and Treatment Center at Texas Oncology–Baylor Charles A. Sammons Cancer Center discusses how somatostatins have been the most game-changing drug in the treatment landscape of gastroenteropancreatic neuroendocrine tumors. Thymomas are the most common tumours of the anterior mediastinum; their clinical course is often complicated by accompanying autoimmune and paraneoplastic .

    Preclinical studies indicate that somatostatin analogues exert inhibitory and suppressive effects in prostate, gastric, lung, colorectal, mammary, thyroid, and pancreatic cell li When octreotide binds to tumors expressing somatostatin receptors, direct effects such as inhibition of the cell cycle and growth factors, and apoptosis occur   Somatostatin receptors and their role in oncology SST can elicit both direct and indirect effects on tumor biology. The direct mechanism involves inhibition of proliferation and/or induction of apoptosis through direct interactions between SST or its analogs and .

    From the prospective of a major oncology center in the United States, somatostatin analog radiopeptides currently have limited diagnostic and therapeutic utility. Diagnostic modalities utilitizing Somatostatin Receptor Imaging are now commercially available and the role of this type of method is currently being evaluated. Most GEP-NETs overexpress the somatostatin receptor SSTR2; somatostatin analogues are the best therapeutic option for functional neuroendocrine tumors because they reduce hormone-related symptoms and also have antitumor effects. Long-acting formulations of somatostatin analogues stabilize tumor growth over long periods.


Share this book
You might also like
economic history 1500-1900 ....

economic history 1500-1900 ....

sou-shen-chi and the Chih-kuai tradition

sou-shen-chi and the Chih-kuai tradition

Economic growth in world perspective

Economic growth in world perspective

Flexible learning in perspective.

Flexible learning in perspective.

Basic writings in Christian education.

Basic writings in Christian education.

knowledge of God in Calvins theology.

knowledge of God in Calvins theology.

William Donald, journalist, and China

William Donald, journalist, and China

penetration of money economy in Japan and its effects upon social and political institutions

penetration of money economy in Japan and its effects upon social and political institutions

Letter from the Assistant Clerk of the Court of Claims, transmitting a copy of the finding of the court in the case of Mary F. Lewis against the United States.

Letter from the Assistant Clerk of the Court of Claims, transmitting a copy of the finding of the court in the case of Mary F. Lewis against the United States.

Roses sing on new snow

Roses sing on new snow

Repairs

Repairs

From Pharaohs lips

From Pharaohs lips

Role of Somatostatin Analogues in Oncology by Kjell Oberg Download PDF EPUB FB2

The book will provide a comprehensive summary of the cellular and molecular biology of somatostatin and its recently isolated receptors.

The book will review the design and use of specific somatostatin analogues both biochemically to characterize the specific functions of somatostatin and clinically in the treatment of various tumors.

Somatostatin analogues (SAs) may have direct and indirect antitumor activity. Octreotide and lanreotide primarily target sstr 2, whereas the new agent pasireotide has high affinity for sstr 1,2,3 and sstr 5.

Methods: Published data evaluating the antitumor properties of SAs in GI tumors were by: 1. Peptides in Oncology II: Somatostatin Analogues and Bombesin Antagonists (Recent Results in Cancer Research) 1st Edition by K. Hoffken (Editor) ISBN ISBN Why is ISBN important. ISBN. This bar-code number lets you verify that you're getting exactly the right version or edition of a book.

The digit and Abstract Peptide receptor scintigraphy with the radioactive somatostatin analogue [ In-DTPA-D-Phe 1 ] octreotide is a sensitive and specific technique to show in vivo the presence and abundance of somatostatin receptors on various by: The Role of Radioactive Somatostatin and Its Analogues in the Control of Tumor Growth.

Pages Preview Buy Chap95 € The Significance of Somatostatin Analogues in the Antiproliferative Treatment of Carcinomas. Pages Kath, R. (et al.) Preview Buy Peptides in Oncology III Book Subtitle Somatostatin and LH-RH Analogues.

Abstract Background. The NETTER-1 trial has recently shown the efficacy of Lu-DOTATATE in association with Octreotide (OCT) in somatostatin receptor positive midgut NETs, progressing to OCT. The aim of this analysis was to evaluate the role of SSA in association to PRRT beyond PD or after switch to other SSA at PD.

Somatostatin analogs (SA) are the standard of care for controlling symptoms of patients with functional gastro-entero-pancreatic neuroendocrine tumors (GEP-NETs). SA control symptoms in more than 70% of patients with carcinoid syndrome.

Similar results are obtained in patients with functional, hormone-secreting, pancreatic NETs. The combination of somatostatin analogues and steroids appears to have a synergistic effect inducing a higher response rate.

Malignant thymoma is a rare tumour. In patients with advanced or recurrent disease, platinum-based palliative chemotherapy is the gold. In addition, somatostatin has an indirect antiproliferative effect on tumors by the inhibition of growth factors and tumor angiogenesis.5 Antiproliferative activity of somatostatin analogs have been demonstrated in breast, kidney, lung, prostate, cervix, and colon cancer studies in vitro.1,3 This activity may be directly related to the inhibition of cell growth signaling pathways, or by indirect Cited by: *immediately available upon purchase as print book shipments may be delayed due to the COVID crisis.

ebook access is temporary and does not include ownership of the ebook. Only valid for books with an ebook version. Springer Reference Works are not included. The development of long-acting somatostatin analogues has provided clinically useful agents for treatment of hormone-producing tumors.

In addition to well-known inhibiting effects on hormone release and actions, recent studies using experimental tumor models have demonstrated an antiproliferative effect of somatostatin and its analogues on growth of a variety of neoplasms. Buy Peptides in Oncology III: Somatostatin and LH-RH Analogues (Recent Results in Cancer Research Book ): Read Kindle Store Reviews - Peptides in Oncology III: Somatostatin and LH-RH Analogues (Recent Results in Cancer Research Book ) - Kindle edition by K.

Höffken, R. Kath. Professional & Technical Kindle eBooks @ The Role of Radioactive Somatostatin and Its Analogues in the Control of Tumor Growth E. Krenning, R. Valkema, P. Kooij, W. Breeman, W. Bakker, W. de Herder et al. Pages Treatment of Endocrine Gastroenteropancreatic Tumors with Somatostatin Analogues.

Peptides in Oncology III: Somatostatin and LH-RH Analogues (Recent Results in Cancer Research): Medicine & Health Science Books @ The edition of ESMO / ASCO Recommendations for a Global Curriculum in Medical Oncology and the edition of the associated Log Book are now. Future studies are designed to answer questions about the role of somatostatin analogs as antiproliferative agents, combinations of biologic therapies, and new cytotoxic chemotherapy backbones.

NETS ARISE from neuroendocrine cells throughout the body, most commonly in the lungs, gastrointestinal tract, and pancreas. Somatostatin and somatostatin analogs inhibit the growth of tumor cells. They also inhibit angiogenesis and growth factors (e.g., insulin‐like growth factor [IGF]–I).

28 In vivo and in vitro data suggest that somatostatin plays an important role in normal and neoplastic thymus, probably by counteracting the local influence of the GH‐IGF.

purpose of this study was to determine by randomized, controlled, double‐blind evaluation whether therapy with the somatostatin analogue, octreotide, would delay tumor progression and improve survival of patients with metastatic colorectal carcinomas who were ambulatory with no significant symptoms.

Müller M.K. () Somatostatin Analogues in the Treatment of Pancreatic Neoplasia. In: Höffken K. (eds) Peptides in Oncology II. Recent Results in Cancer Research, vol Roles of somatostatin analogues in oncology. Uppsala University, Medicinska vetenskapsområdet, Faculty of Medicine, Department of Medical Sciences.

ISBN: OCLC Number: Description: vi, 97 pages: illustrations ; 24 cm. Contents: Role of radioactive somatostatin and its analogues in .Get this from a library!

Peptides in Oncology III: Somatostatin and LH-RH Analogues. [Klaus Höffken; Roland Kath] -- This volume presents the state of the art in the use of somatostatin and LH-RH analogues in neoplastic diseases. It describes their mechanisms of action and the present clinical relevance of these.

Of 15 with EP as the first line, two patients concurrently received octreotide, a somatostatin analogue. Among all 17 patients with the first line chemotherapy, one complete response and six partial responses were observed (overall RR, %).

Stable disease was observed in six patients (%). The DCR was % (Table 3).